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Melatonin modulates cuproptosis and ferroptosis gene expression in aging HGL5 cells We examined melatonins effects on cuproptosis and ferroptosis-related gene expression in aging HGL5 cells (P113)

Abbreviations AAD: American Academy of Dermatology ACD: Allergic contact dermatitis AD: Atopic dermatitis AFU: Adult fingertip units AST: Astaxanthin ASO: Anti-sense oligonucleotide BMV: Betamethasone valerate BSA: Body surface area CAT: COPD assessment tool CHEMS: Cholesteryl hemisuccinate COX-2: Cyclooxygenase-2 CR: Ceramide CsA: Cyclosporin A CS: Chitosan CTAB: Cetyltrimethylammonium bromide DNCB: 1-Chloro-2,4-dinitrobenzene DOPE: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DSPE: Distearoyl-phosphatidylethanolamine DSW: Dead sea water FLG: Filaggrin GCS: Global clinical severity GMS: Glycerylmonostearate GPx-1: Glutathione peroxidase-1 HB: Halobetasol propionate HC: Hydrocortisone HHCL: Hydroxyzine HCL HO-1: Heme oxygenase-1 iNOS: Inducible nitric oxide synthase INF-: Interferon-gamma IGA: Investigators global assessment IL-1: Interleukin-1 IL-1: Interleukin-1 IL-4: Interleukin-4 IL-5: Interleukin-5 IL-6: Interleukin-6 IL-8: Interleukin-8 IL-10: Interleukin-10 IL-12p70: Interleukin-12p70 IL-13: Interleukin-13 IL-18: Interleukin-18 IL-22: Interleukin-22 ITT: Intent to treat KLK: Kallikrein LCs: Langerhans cells MAPK: Mitogen-activated protein kinase MCGs: Membrane-coating granules MDLC: Langerhans cells (LCs) monocyte-derived LC-like cells MMP: Matrix metalloproteinase mRNA: Messenger ribonucleic acid MPO: Myeloperoxidase NLCs: Nano-lipid carriers NCs: Nanocapsules NE: Neutrophil elastase NF-B: Nuclear factor-kappa B NIC: Nicotinamide NPSH: Non-protein thiol OLA: Oleic acid ORG: Oregonin PASI: Psoriasis area and severity index PCL: Poly(-caprolactone) PEG: Poly(ethylene glycol) PGZ: Pioglitazone PLGA: Poly lactic-co-glycolic acid PNPs: Polymeric nanoparticles PVP: Poly vinyl pyrrolidone ROS: Reactive oxygen species SC: Stratum corneum SCORAD: Scoring atopic dermatitis SLNs: Solid lipid nanoparticles SUV: Small uni-lamellar vesicle StNC: Starch-based nanoparticulate system TCR: Tacrolimus TBARS: Thiobarbituric acid reactive species TMSNs: Mesoporous silica nanoparticles loaded with tacrolimus THC: Tetrahydrocurcumin TEOS: Tetraethyl orthosilicate TEWL: Transepidermal water loss Th: T helper TNF-: Tumor necrosis factor-alpha TSLP: Thymic stromal lymphopoietin TSS: Total sign score UVA: Ultraviolet A UVB: Ultraviolet B USFDA: United State Food and Drug administration VAS: Visual analogue scale VEGF: Vascular endothelial growth factor toADSI: Topical atopic dermatitis severity index vIGA-AD: Validated investigator global assessment for atopic dermatitis References Ghosh N, Mitra S, Banerjee ER

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